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2,2,2‐Trifluoroethyl Oxalates in the One‐Pot Parallel Synthesis of Hindered Aliphatic Oxamides
Author(s) -
Bogolubsky Andrey V.,
Moroz Yurii S.,
Mykhailiuk Pavel K.,
Pipko Sergey E.,
Grishchenko Alexander V.,
Zhemera Anton V.,
Konovets Anzhelika I.,
Doroschuk Roman A.,
Dmytriv Yurii V.,
Zaporozhets Olga A.,
Tolmachev Andrey
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501579
Subject(s) - chemistry , oxalate , primary (astronomy) , organic chemistry , combinatorial chemistry , medicinal chemistry , physics , astronomy
A simple parallel synthesis approach to unsymmetrical N 1 , N 2 ‐substituted aliphatic oxamides using methyl (2,2,2‐trifluoroethyl) oxalate and bis(2,2,2‐trifluoroethyl) oxalate was developed. The method was validated on a 52‐membered set of the oxamides, derived mainly from hindered primary and secondary aliphatic amines, and gave the products with a high overall success rate in moderate yields.