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Synthesis of 2,3‐Disubstituted Quinazolinone Derivatives through Copper Catalyzed C–H Amidation Reactions
Author(s) -
Kotipalli Trimurtulu,
Kavala Veerababurao,
Janreddy Donala,
Bandi Vijayalakshmi,
Kuo ChunWei,
Yao ChingFa
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501552
Subject(s) - chemistry , quinazolinone , allylamine , benzylamine , catalysis , amine gas treating , copper , coupling reaction , organic chemistry , combinatorial chemistry , intramolecular force , medicinal chemistry , polymer , polyelectrolyte
Abstract The synthesis of quinazolinone derivatives was achieved from 2‐iodobenzamide derivatives and various benzylamines, allylamine, and cinnamylamine derivatives through a one‐pot copper‐catalyzed reaction. In this reaction, the amine component (benzylamine/allylamine/cinnamylamine) is N ‐arylated with 2‐iodobenzamide derivatives through Ullman coupling, followed by an intramolecular C–H amidation in the presence of copper catalyst.