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A Simple Heterogeneous Catalyst for Phosphite Addition on Carbonyl Groups
Author(s) -
Santacroce Veronica,
Paris Emanuele,
Cauzzi Daniele,
Maggi Raimondo,
Maestri Giovanni
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501434
Subject(s) - chemistry , reagent , hydrotalcite , catalysis , aldehyde , organic chemistry , stoichiometry , condensation , solvent , heterogeneous catalysis , carbonyl group , condensation reaction , combinatorial chemistry , medicinal chemistry , physics , thermodynamics
A cheap and easily recoverable heterogeneous catalyst could efficiently trigger C–P bond formation by selective addition of phosphites to the carbonyl group of aldehydes and ketones. The reactions afford the desired products in good to excellent yields and do not require the presence of a solvent. Furthermore, nearly stoichiometric amounts of reagents could be used as the hydrotalcite catalyst does not cause the condensation of the carbonyl derivatives, even when aliphatic aldehydes are employed.