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Synthesis of Ugi 4‐CR and Passerini 3‐CR Adducts under Mechanochemical Activation
Author(s) -
PolindaraGarcía Luis A.,
Juaristi Eusebio
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501371
Subject(s) - chemistry , mechanochemistry , isocyanide , adduct , ugi reaction , atom economy , environmentally friendly , ball mill , grinding , solvent , combinatorial chemistry , green chemistry , organic chemistry , catalysis , chemical engineering , reaction mechanism , metallurgy , ecology , materials science , engineering , biology
The successful application of a mechanochemical activation strategy that employs high‐speed ball milling (HSBM) conditions for isocyanide‐based multicomponent reactions (IMCRs) was developed. The syntheses of valuable Ugi (by a liquid‐assisted grinding process) and Passerini (under solvent‐free conditions) adducts were achieved by using this method. The protocol disclosed herein allows for the modular synthesis of various compounds according to green chemistry principles, specifically, environmentally friendly conditions, high atom economy, and the absence of toxic byproducts.