TBHP/CoCl 2 ‐Mediated Intramolecular Oxidative Cyclization of  N ‐(2‐Formylphenyl)amides: An Approach to the Construction of 4 H ‐3,1‐Benzoxazin‐4‐ones | Zendy

Yu Junchao | Zendy; ZhangNegrerie Daisy | Zendy; Du Yunfei | Zendy

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TBHP/CoCl 2 ‐Mediated Intramolecular Oxidative Cyclization of N ‐(2‐Formylphenyl)amides: An Approach to the Construction of 4 H ‐3,1‐Benzoxazin‐4‐ones

Author(s) -

Yu Junchao,

ZhangNegrerie Daisy,

Du Yunfei

Publication year - 2016

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201501359

Subject(s) - chemistry , amide , oxidative phosphorylation , aldehyde , catalysis , intramolecular force , medicinal chemistry , organic chemistry , combinatorial chemistry , biochemistry

The intramolecular oxidative cyclization of N ‐(2‐formylphenyl)amides has been realized through an oxidative C(sp 2 )–O(sp 2 ) bond‐forming reaction between an aldehyde carbon and amide oxygen. This new strategy, which uses tert ‐butyl hydroperoxide (TBHP) as an oxidant and CoCl 2 as the catalyst, allows for the efficient Co‐catalyzed synthesis of useful benzoxazin‐4‐one derivatives and features readily available starting materials and mild reaction conditions.

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