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Mono‐ and Difluorination of Benzylic Carbon Atoms
Author(s) -
Koperniku Ana,
Liu Hongqiang,
Hurley Paul B.
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501329
Subject(s) - chemistry , electrophile , nucleophile , fluorine , electrophilic fluorination , base (topology) , medicinal chemistry , carbon fibers , transition metal , catalysis , computational chemistry , organic chemistry , mathematical analysis , mathematics , materials science , composite number , composite material
This microreview is divided into four parts: introduction, benzylic monofluorination, benzylic difluorination and summary. Each procedure (base‐mediated, transition‐metal‐catalyzed, radical‐initiated benzylic fluorination) is described for the cases of both electrophilic and nucleophilic fluorine sources, with the exception of radical‐initiated benzylic difluorination, which is described only in the case of electrophilic fluorine in the literature. Moreover, specifically for radical‐initiated fluorination, the procedures are further classified according to the nature of the radical initiators used.