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Copper Acetate Catalyzed Regioselective Synthesis of Substituted 1,2,3‐Triazoles: A Versatile Azide–Alkene Cycloaddition/Oxidation Approach
Author(s) -
Rohilla Sandeep,
Patel Shyam Sunder,
Jain Nidhi
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501301
Subject(s) - chemistry , cycloaddition , regioselectivity , azide , catalysis , aryl , copper , medicinal chemistry , organic chemistry , combinatorial chemistry , alkyl
A copper acetate catalyzed oxidative cycloaddition reaction of benzyl and aryl azides with terminal and internal olefins that contain electron‐withdrawing groups (COOR, CONH 2 , CN, CHO, COR) has been developed. The reaction employs air as the oxidant and does not require any base or additives to afford 1,4‐disubstituted and 1,4,5‐trisubstituted 1,2,3‐triazoles in good to excellent yields with high regioselectivity.