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Regioselective Coupling Reactions of Coumarins with Aldehydes or Di‐ tert ‐butyl Peroxide (DTBP) through a C(sp 2 )–H Functionalization Process
Author(s) -
Zhao Wannian,
Xu Lei,
Ding Yingcai,
Niu Ben,
Xie Ping,
Bian Zhaogang,
Zhang Denghong,
Zhou Aihua
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501251
Subject(s) - regioselectivity , chemistry , peroxide , coumarin , surface modification , combinatorial chemistry , catalysis , copper , organic chemistry , coupling reaction
Coumarin derivatives are highly valuable compounds in drug discovery. Herein, we have developed two new coupling reactions that involve coumarins and either aldehydes or di‐ tert ‐butyl peroxide (DTBP) in the presence of inexpensive copper or iron catalysts. Both of these reactions proceed through a C(sp 2 )–H functionalization process to regioselectivity generate keto‐ or methyl‐substituted coumarin derivatives in moderate to good yields These coupling reactions will enrich current coumarin chemistry.