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First Catalyzed Hydration of Haloalkynes by a Recyclable Catalytic System
Author(s) -
Zou Huaxu,
He Weibao,
Dong Qizhi,
Wang Ruijia,
Yi Niannian,
Jiang Jun,
Pen Dongming,
He Weimin
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501198
Subject(s) - chemoselectivity , chemistry , catalysis , trifluoroacetic acid , substrate (aquarium) , combinatorial chemistry , scope (computer science) , organic chemistry , oceanography , computer science , programming language , geology
The hydration of haloalkynes to give α‐halomethyl ketones was achieved based on a combination of a Cu(OAc) 2 catalyst and a TFA (trifluoroacetic acid) promoter. This is the first synthesis of chloro/bromo/iodo methyl ketones through a hydration reaction catalyzed by a recyclable catalytic system. The catalytic system has a wide substrate scope and excellent chemoselectivity, and the procedure can also be scaled up.