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Palladium‐Catalyzed Oxidative Direct ortho ‐C–H Acylation of Arenes with Aldehydes under Aqueous Conditions
Author(s) -
Xiao Fuhong,
Chen Shuqing,
Huang Huawen,
Deng GuoJun
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501187
Subject(s) - chemistry , acylation , palladium , regioselectivity , catalysis , aqueous solution , oxidative phosphorylation , organic chemistry , functional group , medicinal chemistry , biochemistry , polymer
Palladium‐catalyzed ortho ‐acylation of arenes with aldehydes in the presence of tert ‐butyl hydroperoxide (TBHP) as the oxidant under aqueous conditions has been demonstrated. The acylation reaction exhibits excellent regioselectivity and wide functional group tolerance.