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Visible‐Light, Metal‐Free α‐Amino C(sp 3 )–H Activation through 1,5‐Hydrogen Migration: A Concise Method for the Preparation of Bis(indolyl)alkanes
Author(s) -
Shaaban Saad,
Roller Alexander,
Maulide Nuno
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501149
Subject(s) - chemistry , surface modification , catalysis , alkane , hydrogen , metal , aryl , photochemistry , transition metal , visible spectrum , organic chemistry , alkyl , physics , optoelectronics
A photoredox catalytic, metal‐free method for C–H functionalization α to amines directly leads to the formation of bis(indolyl)alkane products in good to excellent yields. This transformation hinges on a smooth 1,5‐hydrogen migration to an aryl radical intermediate.