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Iodine‐Catalyzed Synthesis of Highly Functionalized 1 H ‐Indene Derivatives from Michael Adducts of o ‐Alkynylarene Chalcones with Diethyl Malonate
Author(s) -
Akbar Sikkandarkani,
Srinivasan Kannupal
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501141
Subject(s) - chemistry , diethyl malonate , michael reaction , indene , adduct , malonate , isomerization , yield (engineering) , iodine , catalysis , organic chemistry , medicinal chemistry , materials science , metallurgy
Upon treatment with a substoichiometric amount of iodine in ethanol under reflux conditions, the Michael adducts of o ‐alkynylarene chalcones with diethyl malonate underwent 5‐ exo‐dig Conia‐ene cyclization followed by isomerization to yield highly functionalized 1 H ‐indene derivatives in good yields.