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Base‐Induced One‐Pot Preparation of N‐ or P‐Substituted Alkynes
Author(s) -
Zhang Yang,
Zhang Yanqin,
Xiao Jing,
Peng Zhihong,
Dong Wanrong,
An Delie
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501092
Subject(s) - chemistry , heteroatom , yield (engineering) , combinatorial chemistry , base (topology) , catalysis , transition metal , functional group , reaction conditions , medicinal chemistry , stereochemistry , organic chemistry , ring (chemistry) , mathematical analysis , materials science , polymer , mathematics , metallurgy
An efficient method for the formation of C(sp)–N or C(sp)–P bonds is described. The facile transformation proceeds under mild conditions (0 or –20 °C) in a one‐pot manner, and does not require transition‐metal catalysts. The base‐induced protocol exhibits good functional group tolerance (up to 44 examples) and high efficiency (up to 94 % yield) towards rare heteroatom‐substituted acetylenes (N or P). Furthermore, the proposed mechanism was supported by the isolation of a key intermediate.