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Solvent‐Free Ball‐Milling Biginelli Reaction by Subcomponent Synthesis
Author(s) -
Sahoo Prasit Kumar,
Bose Anima,
Mal Prasenjit
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501039
Subject(s) - chemistry , biginelli reaction , ball mill , organic chemistry , chemical engineering , catalysis , engineering
We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof‐of‐concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed under solvent‐free, metal‐free, mechanochemical (ball milling) and ambient laboratory conditions. Br + ‐catalyzed oxidation of benzyl alcohols led to the product benzaldehydes and byproduct H + which were further promoted as component and catalyst, respectively, for a cascade transformation to dihydropyrimidones within the same reaction pot. Remarkably, in solution, the reaction system could not be reproduced at room temperature even after 24 h.