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Palladium‐Catalyzed Regio‐ and Chemoselective Reactions of 2‐Bromobenzyl Bromides: Expanding the Scope for the Synthesis of Biaryls Fused to a Seven‐Membered Sultam
Author(s) -
Laha Joydev K.,
Sharma Shubhra,
Dayal Neetu
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201501032
Subject(s) - chemistry , palladium , intramolecular force , sulfonamide , catalysis , domino , combinatorial chemistry , scope (computer science) , organic chemistry , medicinal chemistry , computer science , programming language
Speedy access to biaryls fused to seven‐membered sultams was achieved by starting from readily accessible N ‐alkylbenzenesulfonamides and 2‐bromobenzyl bromides. The protocol features a domino reaction and proceeds through an N ‐benzylation followed by an intramolecular direct C–H arylation that occurs ortho to the sulfonamide group.