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Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin–Platinum(II) Complex
Author(s) -
D'Errico Stefano,
Oliviero Giorgia,
Borbone Nicola,
Di Gennaro Elena,
Zotti Andrea Ilaria,
Budillon Alfredo,
Cerullo Vincenzo,
Nici Fabrizia,
Mayol Luciano,
Piccialli Vincenzo,
Piccialli Gennaro
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500998
Subject(s) - chemistry , cisplatin , deoxyguanosine , nucleoside , sulforhodamine b , purine , stereochemistry , platinum , combinatorial chemistry , biochemistry , dna , in vitro , cytotoxicity , catalysis , enzyme , medicine , surgery , chemotherapy
Herein, the synthesis of a nucleoside platinum(II) complex in which a cisplatin‐like unit is joined to 7‐deazaadenosine through an amino alkyl chain installed at the C6 position of purine was explored. The capability of the new complex to react with DNA purine bases was confirmed by a model reaction with deoxyguanosine monophosphate, whereas its antiproliferative activity against A549 and Cal27 human cancer cell lines was studied by sulforhodamine B assay in comparison with its unplatinated precursor and cisplatin.