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A Modularly Designed Supramolecular Organocatalyst as an Effective Stimulant for the Highly Asymmetric Michael Addition of Ketones to Nitro Olefins
Author(s) -
Ramachary Dhevalapally B.,
Shruthi Kodambahalli S.,
Madhavachary R.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500994
Subject(s) - chemistry , michael reaction , nitro , chemoselectivity , organocatalysis , supramolecular chemistry , ketone , olefin fiber , combinatorial chemistry , organic chemistry , catalysis , enantioselective synthesis , molecule , alkyl
The asymmetric modularly designed supramolecular organocatalytic nitro olefin–ketone Michael addition of a variety of functionally rich nitro olefins with ketones was explored. The modularly designed supramolecular organocatalytic Michael reaction is characterized by a high rate, high chemoselectivity, high diastereoselectivity, high enantioselectivity, mild reaction conditions, readily available substrates/catalysts with simple operations, and excellent yields with a broad spectrum of functionally rich substrates. This method constitutes an alternative to previously known organocatalytic Michael reactions.