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Synthesis of Indoles by Palladium‐Catalyzed Reductive Cyclization of β‐Nitrostyrenes with Carbon Monoxide as the Reductant
Author(s) -
Ferretti Francesco,
ELAtawy Mohamed A.,
Muto Stefania,
Hagar Mohamed,
Gallo Emma,
Ragaini Fabio
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500933
Subject(s) - chemistry , catalysis , carbon monoxide , palladium , combinatorial chemistry , organic chemistry
An efficient catalytic cyclization of β‐nitrostyrenes to indoles was developed. The reaction was applied to the synthesis of 3‐arylindoles and 2‐alkylindoles. Given that in the latter case the starting β‐nitrostyrenes can be easily obtained by a Henry reaction, the present method allows indoles to be obtained in a two‐step sequence starting from cheap reactants.