Premium
Direct [ 11 C]Methylation of Amines from [ 11 C]CO 2 for the Synthesis of PET Radiotracers
Author(s) -
Liger François,
Eijsbouts Ture,
Cadarossanesaib Florence,
Tourvieille Christian,
Le Bars Didier,
Billard Thierry
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500924
Subject(s) - radiochemistry , chemistry , positron emission tomography , methylation , pet imaging , nuclear medicine , biochemistry , medicine , dna
[ 11 C]Methylation ( t 1/2 = 20.4 min) is a main labeling strategy for the development of PET (positron emission tomography) radiotracers. A straight radiomethylation of amines with cyclotron‐produced 11 CO 2 has been developed to obtain various radiolabeled compounds with good radiochemical yields. This strategy is a new approach to simplifying radiolabeling processes and transpositions onto automatic synthesizers and has been applied to the synthesis of radiolabeled drugs and a PET radiotracer used in the study of Alzheimer's disease.