Direct [ 11 C]Methylation of Amines from [ 11 C]CO 2  for the Synthesis of PET Radiotracers | Zendy

Liger François | Zendy; Eijsbouts Ture | Zendy; Cadarossanesaib Florence | Zendy; Tourvieille Christian | Zendy; Le Bars Didier | Zendy; Billard Thierry | Zendy

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Direct [ 11 C]Methylation of Amines from [ 11 C]CO 2 for the Synthesis of PET Radiotracers

Author(s) -

Liger François,

Eijsbouts Ture,

Cadarossanesaib Florence,

Tourvieille Christian,

Le Bars Didier,

Billard Thierry

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500924

Subject(s) - radiochemistry , chemistry , positron emission tomography , methylation , pet imaging , nuclear medicine , biochemistry , medicine , dna

[ 11 C]Methylation ( t 1/2 = 20.4 min) is a main labeling strategy for the development of PET (positron emission tomography) radiotracers. A straight radiomethylation of amines with cyclotron‐produced 11 CO 2 has been developed to obtain various radiolabeled compounds with good radiochemical yields. This strategy is a new approach to simplifying radiolabeling processes and transpositions onto automatic synthesizers and has been applied to the synthesis of radiolabeled drugs and a PET radiotracer used in the study of Alzheimer's disease.

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