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Investigations of the Thermal Responsiveness of 1,4,2‐Oxathiazoles
Author(s) -
Hewitt Russell J.,
Ong Michelle Jui Hsien,
Lim Yi Wee,
Burkett Brendan A.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500909
Subject(s) - chemistry , substituent , fragmentation (computing) , stereochemistry , operating system , computer science
The first systematic study of the thermal rearrangement/fragmentation of 5,5‐disubstituted 1,4,2‐oxathiazoles into isothiocyanates is reported. Structure–activity relationships reveal that the choice of substituent at the 5‐position of the 1,4,2‐oxathiazoles is the predominant factor to influence the ease of fragmentation.