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Lewis‐Acid‐Catalysed Friedel–Crafts Alkylation of Donor–Acceptor Cyclopropanes with Electron‐Rich Benzenes to Generate 1,1‐Diarylalkanes
Author(s) -
Kim Areum,
Kim SungGon
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500856
Subject(s) - friedel–crafts reaction , chemistry , lewis acids and bases , alkylation , yield (engineering) , catalysis , acceptor , organic chemistry , electrophilic aromatic substitution , electron acceptor , ring (chemistry) , medicinal chemistry , materials science , physics , metallurgy , condensed matter physics
A Lewis‐acid‐catalysed Friedel–Crafts alkylation of donor–acceptor cyclopropanes with electron‐rich aromatic compounds is described. The reaction uses Yb(OTf) 3 as the catalyst, producing the desired Friedel–Crafts products with a wide range of functional groups and substitution patterns in good yield. This synthetic approach allows the construction of 1,1‐diarylalkane derivatives, which are present in numerous biologically active compounds.