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Synthesis of Allyl Carbamates through the Regioselective Domino Reaction of Amines, CO 2 , and Unsymmetrical Allyl Chlorides under Pd Catalysis
Author(s) -
Cai Juewang,
Zhang Min,
Zhao Xiaoming
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500769
Subject(s) - regioselectivity , chemistry , catalysis , palladium , domino , amination , reaction conditions , medicinal chemistry , cascade reaction , organic chemistry , combinatorial chemistry
The regioselective domino reaction of CO 2 (1 atm), amines, and unsymmetrical allyl chlorides in the presence of a palladium complex and K 3 PO 4 under mild conditions to provide allyl carbamates in good yields with excellent regioselectivity (99:1) was accomplished.