Synthesis of Silodosin by Copper‐Catalysed C–C Arylation | Zendy

Calogero Francesco | Zendy; Allegrini Pietro | Zendy; Attolino Emanuele | Zendy; Passarella Daniele | Zendy

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Synthesis of Silodosin by Copper‐Catalysed C–C Arylation

Author(s) -

Calogero Francesco,

Allegrini Pietro,

Attolino Emanuele,

Passarella Daniele

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500753

Subject(s) - silodosin , chemistry , enantiopure drug , indoline , amination , cyanation , combinatorial chemistry , regioselectivity , reductive amination , copper , enantioselective synthesis , stereochemistry , organic chemistry , catalysis , prostate , lower urinary tract symptoms , medicine , cancer

The synthesis of silodosin, an antidysuria drug, has been accomplished starting from commercially available indoline. The synthetic strategy is based on Cu I ‐catalysed C–C arylation, regioselective cyanation, and diastereoselective reductive amination. The enantiopure compound was obtained by selective crystallisation of a diasteroisomeric mixture.

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