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Acid‐Catalyzed Synthesis of α‐Trifluoromethylthiolated Carbonyl Compounds
Author(s) -
Alazet Sébastien,
Ismalaj Ermal,
Glenadel Quentin,
Le Bars Didier,
Billard Thierry
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500710
Subject(s) - chemistry , catalysis , combinatorial chemistry , base (topology) , organic chemistry , aldehyde , molecule , mathematical analysis , mathematics
The α‐trifluoromethylthiolation of carbonyl compounds in soft acidic conditions has been developed. With this method only mono‐trifluoromethylthiolation was selectively observed. Base‐sensitive ketones can then be trifluoromethylthiolated. More sensitive aldehydes are also trifluoromethylthiolated under these conditions with good yields. This work provides a new route towards the synthesis of various valuable trifluoromethylthiolated molecules.