An Efficient Stereoselective Total Synthesis of All Stereoisomers of the Antibiotic Thiamphenicol through Ruthenium‐Catalyzed Asymmetric Reduction by Dynamic Kinetic Resolution | Zendy

Perez Marc | Zendy; Echeverria PierreGeorges | Zendy; MartinezArripe Elsa | Zendy; Ez Zoubir Mehdi | Zendy; Touati Ridha | Zendy; Zhang Zhaoguo | Zendy; Genet JeanPierre | Zendy; Phansavath Phannarath | Zendy; Ayad Tahar | Zendy; RatovelomananaVidal Virginie | Zendy

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An Efficient Stereoselective Total Synthesis of All Stereoisomers of the Antibiotic Thiamphenicol through Ruthenium‐Catalyzed Asymmetric Reduction by Dynamic Kinetic Resolution

Author(s) -

Perez Marc,

Echeverria PierreGeorges,

MartinezArripe Elsa,

Ez Zoubir Mehdi,

Touati Ridha,

Zhang Zhaoguo,

Genet JeanPierre,

Phansavath Phannarath,

Ayad Tahar,

RatovelomananaVidal Virginie

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500661

Subject(s) - thiamphenicol , kinetic resolution , chemistry , ruthenium , enantioselective synthesis , stereoselectivity , combinatorial chemistry , catalysis , stereochemistry , resolution (logic) , transfer hydrogenation , antibiotics , organic chemistry , chloramphenicol , biochemistry , artificial intelligence , computer science

Thiamphenicol is a widely used antibiotic that exhibits activity against numerous Gram‐positive and Gram‐negative pathogens. Here, we describe the expedient synthesis of its four stereoisomers through a dynamic kinetic resolution that follows a ruthenium‐catalyzed asymmetric hydrogenation or a hydrogen transfer reaction as the key step.

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