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Nickel‐Catalyzed Decarbonylative Coupling of Aryl Esters and Arylboronic Acids
Author(s) -
LaBerge Nicole A.,
Love Jennifer A.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500630
Subject(s) - chemistry , catalysis , aryl , palladium , nickel , organic chemistry , combinatorial chemistry , alkyl
A variety of functionalized biaryls can be accessed by coupling aryl and heteroaryl esters with boronic acids in Suzuki–Miyaura‐type decarbonylative cross‐coupling catalyzed by an affordable catalyst system composed of Ni(cod) 2 and PCy 3 . The methodology is tolerant of a variety of functional groups and presents an attractive alternative to the use of palladium catalysis currently used in industry to acquire such bis(hetero)aryls, but also reveals challenges associated with nickel catalysis of esters in cross‐coupling chemistry.