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Synthesis of 2,1‐Borazaroquinolines and 2,1‐Borazaroisoquinolines from Vinylaminopyridines and Potassium Organotrifluoroborates by Microwave‐Assisted Heating
Author(s) -
Sánchez Casado M. Rosa,
Ciordia Jiménez Myriam,
Ariza Bueno Manuela,
Barriol Morgane,
Leenaerts Joseph E.,
Pagliuca Chiara,
Martínez Lamenca Carolina,
De Lucas Ana Isabel,
García Aránzazu,
Trabanco Andrés A.,
Rombouts Frederik J. R.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500622
Subject(s) - aminopyridines , chemistry , potassium , microwave , combinatorial chemistry , microwave heating , organic chemistry , nanotechnology , telecommunications , materials science , computer science
Azaborines are an emerging class of compounds with applications in medicinal chemistry and materials science. The synthesis of a wide variety of borazaronaphthalenes has been reported in the last decade. However, access to other borazaro derivatives has been limited. A new approach to synthesize 2,1‐borazaroquinolines and 2,1‐borazaroisoquinolines from (vinylamino)pyridines and potassium organotrifluoroborates using microwave‐assisted heating is reported. A substituted diverse set of new azaborines has been synthesized by this method, providing the first access to a family of 2,1‐borazaroquinolines and 2,1‐borazaroisoquinolines.