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Synthesis of Polycycles by Single or Double Domino Nucleophilic Substitution/Diels–Alder Reaction
Author(s) -
Camps Pelayo,
Lozano David,
FontBardia Mercè
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500601
Subject(s) - chemistry , domino , intramolecular force , nucleophilic substitution , cycloaddition , diels–alder reaction , nucleophile , nucleophilic addition , substitution reaction , potassium , medicinal chemistry , stereochemistry , organic chemistry , catalysis
New hexacyclo and octacyclo compounds have been synthesized by a short route whose key step consists of a single or double domino nucleophilic substitution of neopentyl‐type iodides with potassium cyclopentadienide, followed by intramolecular Diels–Alder cycloaddition.