CF 3 ‐Carbenoid C–H Functionalization of (Hetero)arenes under Chelation‐Controlled Rh III  Catalysis | Zendy

Iagafarova Irina E. | Zendy; Vorobyeva Daria V. | Zendy; Peregudov Alexander S. | Zendy; Osipov Sergey N. | Zendy

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CF 3 ‐Carbenoid C–H Functionalization of (Hetero)arenes under Chelation‐Controlled Rh III Catalysis

Author(s) -

Iagafarova Irina E.,

Vorobyeva Daria V.,

Peregudov Alexander S.,

Osipov Sergey N.

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500545

Subject(s) - carbenoid , chemistry , chelation , regioselectivity , catalysis , carboxylate , surface modification , medicinal chemistry , stereochemistry , rhodium , organic chemistry

An efficient method for the CF 3 ‐carbenoid C–H functionalization of benzenes and indoles using readily available methyl 3,3,3‐trifluoro‐2‐diazopropionate as a cross‐coupling partner under chelation‐controlled Rh III catalysis has been developed. The reactions proceeded smoothly with high regioselectivity in a few hours and allowed the simultaneous introduction of CF 3 and carboxylate functions into the 2‐position of directing‐group‐containing benzenes and indoles.

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