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CF 3 ‐Carbenoid C–H Functionalization of (Hetero)arenes under Chelation‐Controlled Rh III Catalysis
Author(s) -
Iagafarova Irina E.,
Vorobyeva Daria V.,
Peregudov Alexander S.,
Osipov Sergey N.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500545
Subject(s) - carbenoid , chemistry , chelation , regioselectivity , catalysis , carboxylate , surface modification , medicinal chemistry , stereochemistry , rhodium , organic chemistry
An efficient method for the CF 3 ‐carbenoid C–H functionalization of benzenes and indoles using readily available methyl 3,3,3‐trifluoro‐2‐diazopropionate as a cross‐coupling partner under chelation‐controlled Rh III catalysis has been developed. The reactions proceeded smoothly with high regioselectivity in a few hours and allowed the simultaneous introduction of CF 3 and carboxylate functions into the 2‐position of directing‐group‐containing benzenes and indoles.