Metal‐Free Intramolecular Alkyne‐Azide Cycloaddition To Construct the Pyrazolo[4,3‐ f ][1,2,3]triazolo[5,1‐ c ][1,4]oxazepine Ring System | Zendy

Arbačiauskienė Eglė | Zendy; Laukaitytė Vaida | Zendy; Holzer Wolfgang | Zendy; Šačkus Algirdas | Zendy

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Metal‐Free Intramolecular Alkyne‐Azide Cycloaddition To Construct the Pyrazolo[4,3‐ f ][1,2,3]triazolo[5,1‐ c ][1,4]oxazepine Ring System

Author(s) -

Arbačiauskienė Eglė,

Laukaitytė Vaida,

Holzer Wolfgang,

Šačkus Algirdas

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500541

Subject(s) - cycloaddition , intramolecular force , chemistry , alkyne , azide , ring (chemistry) , stereochemistry , click chemistry , crystallography , combinatorial chemistry , organic chemistry , catalysis

A simple and efficient synthetic route to a new pyrazolo[4,3‐ f ][1,2,3]triazolo[5,1‐ c ][1,4]oxazepine ring system has been developed by employing a metal‐free, intramolecular alkyne‐azide cycloaddition reaction as the key step. The structures of the obtained heterocyclic products were unequivocally confirmed by detailed 1 H, 13 C, and 15 N NMR spectroscopic experiments and single‐crystal X‐ray diffraction analysis.

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