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Arsenical C ‐Glucoside Derivatives with Promising Antitumor Activity
Author(s) -
D'Orazio Giuseppe,
Parisi Gelsomina,
Policano Claudia,
Mechelli Rosella,
Codacci Pisanelli Giovanni,
Pitaro Michele,
Ristori Giovanni,
Salvetti Marco,
Nicotra Francesco,
La Ferla Barbara
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500529
Subject(s) - chemistry , moiety , glucoside , covalent bond , stereochemistry , cell culture , arsenic , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology , biology , genetics
C ‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1 , bearing an As V atom, did not show any significant biological activity, compound 2 , in which the glucose moiety is linked to the arsenic atom as dithioarsenical (As III ), showed promising antiproliferative activity on a cell line of neuroblastoma (SK‐N‐BE).