Arsenical  C ‐Glucoside Derivatives with Promising Antitumor Activity | Zendy

D'Orazio Giuseppe | Zendy; Parisi Gelsomina | Zendy; Policano Claudia | Zendy; Mechelli Rosella | Zendy; Codacci Pisanelli Giovanni | Zendy; Pitaro Michele | Zendy; Ristori Giovanni | Zendy; Salvetti Marco | Zendy; Nicotra Francesco | Zendy; La Ferla Barbara | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Arsenical C ‐Glucoside Derivatives with Promising Antitumor Activity

Author(s) -

D'Orazio Giuseppe,

Parisi Gelsomina,

Policano Claudia,

Mechelli Rosella,

Codacci Pisanelli Giovanni,

Pitaro Michele,

Ristori Giovanni,

Salvetti Marco,

Nicotra Francesco,

La Ferla Barbara

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500529

Subject(s) - chemistry , moiety , glucoside , covalent bond , stereochemistry , cell culture , arsenic , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology , biology , genetics

C ‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound 1 , bearing an As V atom, did not show any significant biological activity, compound 2 , in which the glucose moiety is linked to the arsenic atom as dithioarsenical (As III ), showed promising antiproliferative activity on a cell line of neuroblastoma (SK‐N‐BE).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research