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Pd‐Catalyzed Allylic Alkynylation of Allylic Acetates with Terminal Alkynes
Author(s) -
Yang Qingjing,
Zhou Yongyun,
Chen Jingchao,
He Xiaobo,
Xu Jianbin,
Kwong Fuk Yee,
Fan Baomin
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500522
Subject(s) - allylic rearrangement , chemistry , alkynylation , catalysis , palladium , yield (engineering) , organic chemistry , combinatorial chemistry , medicinal chemistry , materials science , metallurgy
The first palladium‐catalyzed allylic alkynylation reaction of allylic acetates with terminal alkynes has been realized. By empolying AgOTf as a cooperative catalyst, 1,4‐enynes were synthesized in up to 98 % yield under mild conditions. Moreover, the possible asymmetric version of this allylic alkynylation reaction was demonstrated.