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Catalytic Enantioselective Synthesis of α‐(Benzylamino)cyclobutanones
Author(s) -
Melis Nicola,
Ghisu Lorenza,
Guillot Régis,
Caboni Pierluigi,
Secci Francesco,
Aitken David J.,
Frongia Angelo
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500460
Subject(s) - chemistry , enantioselective synthesis , intramolecular force , tandem , catalysis , condensation , combinatorial chemistry , stereochemistry , organic chemistry , materials science , physics , composite material , thermodynamics
An organocatalytic enantioselective synthesis of α‐(benzylamino)cyclobutanones has been achieved by employing a tandem condensation/intramolecular rearrangement/proton transfer reaction and starting from racemic α‐hydroxycyclobutanone and a selection of benzylamines. This reaction sequence afforded the products in good to high yields with moderate to high enantioselectivities.