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Chemoselective Pd‐Catalyzed Isocyanide Insertion Reaction of Enaminones by C–H Functionalization: Hydrolysis or Cyclization through 1,3‐Palladium Migration
Author(s) -
Gu ZhengYang,
Wang Xiang,
Cao JiaJia,
Wang ShunYi,
Ji ShunJun
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500458
Subject(s) - chemistry , palladium , isocyanide , surface modification , amide , catalysis , hydrolysis , combinatorial chemistry , chemoselectivity , organic chemistry , polymer chemistry
Abstract A chemoselective palladium‐catalyzed isocyanide insertion reaction of enaminones was developed. Amide derivatives were synthesized by this C–H functionalization and subsequent hydrolysis reactions. 4‐Aminoquinoline derivatives were prepared by this C–H functionalization, which includes a 1,3‐palladium migration in the process.