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4′‐Selenonucleosides as Next‐Generation Nucleosides
Author(s) -
Sahu Pramod K.,
Naik Siddhi D.,
Yu Jinha,
Jeong Lak Shin
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500429
Subject(s) - chemistry , moiety , ring (chemistry) , drug discovery , combinatorial chemistry , stereochemistry , nanotechnology , organic chemistry , biochemistry , materials science
Modified nucleosides continue to hold their position as one of the most fruitful classes of therapeutic agents in drug discovery. One fairly recent modification involves bioisosteric introduction of selenium at the 4′‐position of the sugar ring, with the aim of overcoming the drawbacks of previous‐generation 4′‐oxo‐, 4′‐carba‐, and 4′‐thionucleosides. This review highlights the development of new 4′‐selenonucleosides, summarizing various synthetic strategies involved in several prime modifications on the 4‐selenosugar moiety.