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Peptide‐Catalyzed Desymmetrization of an Achiral Ferrocenyl Compound To Induce Planar Chirality
Author(s) -
Akagawa Kengo,
Akiyama Midori,
Kudo Kazuaki
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500428
Subject(s) - desymmetrization , chemistry , kinetic resolution , planar chirality , catalysis , chirality (physics) , peptide , enantioselective synthesis , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , chiral symmetry breaking , physics , quantum mechanics , quark , nambu–jona lasinio model
Selective monohydrogenation of an achiral ferrocenebis(enal) was achieved with a resin‐supported peptide catalyst to afford an enantioenriched planar‐chiral product. It was also demonstrated that the reaction was followed by a kinetic resolution through cyclization of the product.