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A One‐Pot Synthesis of Triazolodiazepines
Author(s) -
Hooyberghs Geert,
Van Hove Sofie,
Jacobs Jeroen,
Van Meervelt Luc,
Van der Eycken Erik V.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500402
Subject(s) - chemistry , combinatorial chemistry , diazepine , coupling reaction , structural motif , stereochemistry , organic chemistry , catalysis , ring (chemistry) , biochemistry
Abstract A one‐pot sequential A 3 ‐coupling‐azidation‐cyclisation approach leading to potentially biologically active diazepine analogues has been developed. The implementation of the A 3 ‐coupling reaction ensures diversity. Attention is given to this so far rarely studied structural motif of fused heterocyclic diazepines.