Nucleophilic‐Bisphosphine‐Catalysed One‐Pot Sequential [4+2]/[4+2] Annulation of an Allenoate with Benzylidenepyrazolones | Zendy

Jia Yu | Zendy; Tang Xiao | Zendy; Cai Guowei | Zendy; Jia Ruxuan | Zendy; Wang Boran | Zendy; Miao Zhiwei | Zendy

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Nucleophilic‐Bisphosphine‐Catalysed One‐Pot Sequential [4+2]/[4+2] Annulation of an Allenoate with Benzylidenepyrazolones

Author(s) -

Jia Yu,

Tang Xiao,

Cai Guowei,

Jia Ruxuan,

Wang Boran,

Miao Zhiwei

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500399

Subject(s) - annulation , chemistry , nucleophile , catalysis , pyrazole , butane , naphthalene , medicinal chemistry , organic chemistry , combinatorial chemistry

An efficient bisphosphine‐catalysed sequential [4+2]/[4+2] annulation reaction of a γ‐benzyl allenoate with benzylidenepyrazolones has been developed. Under the catalysis of DPPB [1,3‐bis(diphenylphosphanyl)butane], the [4+2]/[4+2] annulation proceeded smoothly to give spiro‐pyrazolidinone derivatives in moderate yields. This protocol provides a simple and practical strategy for the construction of highly substituted 2 H ‐spiro[naphthalene‐pyrazole] skeletons.

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