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Synthesis of a P ‐Stereogenic PNP t Bu,Ph Ruthenium Pincer Complex and Its Application in Asymmetric Reduction of Ketones
Author(s) -
Arenas Ismael,
Boutureira Omar,
Matheu M. Isabel,
Díaz Yolanda,
Castillón Sergio
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500389
Subject(s) - chemistry , stereocenter , ruthenium , pincer movement , medicinal chemistry , catalysis , enantioselective synthesis , stereochemistry , asymmetric hydrogenation , combinatorial chemistry , organic chemistry
Abstract A novel P ‐stereogenic PNP t Bu,Ph ruthenium complex has been synthesized and characterized enabling the asymmetric hydrogenation of a wide range of aromatic ketones with excellent catalytic activities (up to 98 % conversion) and good levels of enantiodiscrimination (up to 95 % ee ).