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Copper(I)‐Mediated Direct Trifluoromethylthiolation of Allylic Halides with Elemental Sulfur and (Trifluoromethyl)trimethylsilane
Author(s) -
Li Jue,
Wang Peiqiang,
Xie FeiFei,
Yang XiGang,
Song XiaoNan,
Chen WeiDong,
Ren Jiangmeng,
Zeng BuBing
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500384
Subject(s) - chemistry , allylic rearrangement , trifluoromethyl , trifluoromethylation , halide , sulfur , copper , anhydrous , potassium fluoride , halogenation , organic chemistry , fluoride , medicinal chemistry , inorganic chemistry , catalysis , alkyl
A new method has been developed for the copper‐mediated trifluoromethylthiolation of allylic halides by using potassium fluoride, elemental sulfur, and (trifluoromethyl)trimethylsilane in anhydrous N , N ‐dimethylformamide. This protocol provides facile access to a variety of allylic trifluoromethyl thioethers in moderate to good yields under mild, ligand‐free reaction conditions.