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Synthesis and Biological Evaluation of Dichlorinated Chondramide Derivatives
Author(s) -
Becker Dominic,
Kazmaier Uli
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500369
Subject(s) - chemistry , polyketide , stereochemistry , methyl group , biological activity , combinatorial chemistry , group (periodic table) , organic chemistry , biosynthesis , biochemistry , in vitro , enzyme
Straightforward synthetic protocols for the synthesis of new ethyl‐substituted dichlorinated chondramides with different methyl‐substitution patterns in the polyketide fragment have been developed. The methyl groups at the ϵ‐position can be removed completely without a significant influence on the biological activity. In contrast, after removal of the α‐methyl group, a significant drop in activity is observed. This is also observed if the configuration of the α‐methyl group is inverted.