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A Facile One‐Pot Metal‐Free Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles
Author(s) -
Jia Qianfa,
Yang Gongming,
Chen Lei,
Du Zhiyun,
Wei Jia,
Zhong Yanqiong,
Wang Jian
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500360
Subject(s) - regioselectivity , chemistry , cycloaddition , combinatorial chemistry , 1,3 dipolar cycloaddition , organic chemistry , one pot synthesis , catalysis
A 1,3‐dipolar cycloaddition reaction of commercially available aldehydes with azides and secondary amines through a one‐pot strategy has been developed. This method furnishes 1,4‐disubstituted 1,2,3‐triazoles in good to excellent yields and high levels of regioselectivity.