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Gold‐ and Silver‐Catalyzed 7‐ endo ‐ dig Cyclizations for the Synthesis of Oxazepines
Author(s) -
Peshkov Anatoly A.,
Nechaev Anton A.,
Pereshivko Olga P.,
Goeman Jan L.,
Van der Eycken Johan,
Peshkov Vsevolod A.,
Van der Eycken Erik V.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500357
Subject(s) - chemistry , dig , amide , catalysis , ring (chemistry) , combinatorial chemistry , stereochemistry , organic chemistry , world wide web , computer science
Abstract A comprehensive study on gold‐ and silver‐catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. Three different types of hydroxypropargylamide substrates derived from either amide coupling or Ugi reactions have been validated resulting in establishment of selective and general access to a medium‐ring oxazepine core.