Palladium‐Catalyzed Nucleophilic Substitution of Propargylic Carbonates and Meldrum's Acid Derivatives | Zendy

Ambrogio Ilaria | Zendy; Cacchi Sandro | Zendy; Fabrizi Giancarlo | Zendy; Goggiamani Antonella | Zendy; Iazzetti Antonia | Zendy

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Palladium‐Catalyzed Nucleophilic Substitution of Propargylic Carbonates and Meldrum's Acid Derivatives

Author(s) -

Ambrogio Ilaria,

Cacchi Sandro,

Fabrizi Giancarlo,

Goggiamani Antonella,

Iazzetti Antonia

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500337

Subject(s) - chemistry , palladium , nucleophilic substitution , catalysis , meldrum's acid , stereoselectivity , substitution (logic) , substitution reaction , medicinal chemistry , nucleophile , organic chemistry , computer science , programming language

The palladium‐catalyzed reaction of propargylic carbonates with Meldrum's acid derivatives proceeds smoothly in the presence of Pd(OAc) 2 and P(2‐furyl) 3 in THF at 80 °C to give substitution products. The substitution products can be useful intermediates for the stereoselective synthesis of functionalized ( Z )‐γ‐alkylidene‐γ‐butyrolactones.

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