A C‐3‐Selective Direct Alkylation of Coumarins by Using a Microwave‐Assisted Xanthate‐Based Radical Reaction | Zendy

Miranda Luis D. | Zendy; IceloÁvila Estefanía | Zendy; RenteríaGómez Ángel | Zendy; Pila Michell | Zendy; Marrero Joaquín G. | Zendy

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A C‐3‐Selective Direct Alkylation of Coumarins by Using a Microwave‐Assisted Xanthate‐Based Radical Reaction

Author(s) -

Miranda Luis D.,

IceloÁvila Estefanía,

RenteríaGómez Ángel,

Pila Michell,

Marrero Joaquín G.

Publication year - 2015

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201500322

Subject(s) - chemistry , xanthate , alkylation , coumarin , selectivity , ring (chemistry) , photochemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis

A xanthate‐based oxidative radical process for the direct alkylation of the coumarin ring system is presented. In the reaction, a vinylic and unactivated C–H bond of the coumarin system is replaced by an α‐acyl functionality under neutral conditions. This reaction has a high reaction site selectivity, which can realize alkylation at the C‐3 position.

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