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Practical Synthesis of Polysubstituted Haloimidazoles from 1,1‐Dibromoalkenes and Amidines
Author(s) -
Li Yibiao,
Cheng Liang,
Shao Yan,
Jiang Shaohua,
Cai Jialing,
Qing Ning
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500305
Subject(s) - chemoselectivity , chemistry , catalysis , combinatorial chemistry , ligand (biochemistry) , organic chemistry , reaction conditions , copper , biochemistry , receptor
The copper‐catalyzed cycloamination reaction of 1,1‐dibromoalkenes with amidines affords a diverse set of polysubstituted haloimidazole derivatives. By using this strategy, high regio‐ and chemoselectivity has been achieved, using 4,7‐diphenyl‐1,10‐phenanthroline as ligand without the addition of expensive catalysts to provide moderate to good yields.