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Palladium‐Catalyzed Direct C–H Arylation of Dicyanobenzenes
Author(s) -
Ihanainen Netta E.,
Kumpulainen Esa T. T.,
Koskinen Ari M. P.
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500288
Subject(s) - chemistry , palladium , aryl , catalysis , combinatorial chemistry , functional group , medicinal chemistry , organic chemistry , alkyl , polymer
A direct palladium‐catalyzed C–H arylation method to synthesize biaryls from dicyanobenzenes has been developed. The reaction is selective towards C2‐arylation of 1,3‐dicyanobenzene and provides biaryls from both electron‐rich and electron‐poor aryl bromides containing para and meta substituents. A variety of functional groups are tolerated, and yields up to 83 % can be obtained. The methodology can be extended to C–H activation of other electron‐deficient benzonitriles.