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N ‐(1‐Oxy‐2‐picolyl)oxalamic Acid as an Efficient Ligand for Copper‐Catalyzed Amination of Aryl Iodides at Room Temperature
Author(s) -
Wang Yongbin,
Ling Jing,
Zhang Yu,
Zhang Ao,
Yao Qizheng
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500279
Subject(s) - chemistry , amination , catalysis , halide , aryl , ligand (biochemistry) , ammonia , copper , medicinal chemistry , organic chemistry , amine gas treating , primary (astronomy) , functional group , combinatorial chemistry , polymer chemistry , polymer , biochemistry , receptor , physics , astronomy , alkyl
N ‐(1‐Oxy‐pyridin‐2‐ylmethyl)oxalamic acid was identified as efficient ligand for CuI‐catalyzed amination of aryl halides at room temperature. In our catalytic system, N ‐arylation of cyclic secondary amines, primary amines, amino acids, and ammonia proceeded with moderate to excellent yields and high functional group tolerance.