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Advancements in Aminofluorination of Alkenes and Alkynes: Convenient Access to β‐Fluoroamines
Author(s) -
Chen Pinhong,
Liu Guosheng
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500231
Subject(s) - chemistry , electrophile , organic chemistry , combinatorial chemistry , amine gas treating , nanotechnology , catalysis , materials science
Direct aminofluorination of alkenes enables the convenient synthesis of β‐fluorinated amine compounds, which are important and valuable skeletons in medicinal chemistry. In recent years this research field has received much attention and significant advancements have been made by different approaches. In this review, recently disclosed methodologies for the production of β‐fluorinated amines, based on electrophilic and metal‐catalyzed processes, are summarized and discussed. Finally, the outlook and perspectives for aminofluorination are also discussed.

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