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Solvent‐Free Synthesis of 4 H ‐Pyrido[1,2‐ a ]pyrimidin‐4‐ones Catalyzed by BiCl 3 : A Green Route to a Privileged Backbone
Author(s) -
Roslan Irwan I.,
Lim QiuXuan,
Han Aijuan,
Chuah GaikKhuan,
Jaenicke Stephan
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500227
Subject(s) - chemistry , catalysis , solvent , reaction conditions , combinatorial chemistry , alcohol , organic chemistry
An extensive array of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones have been synthesized from commercially available 2‐aminopyridines and β‐oxo esters with excellent yields under solvent‐free conditions. The reaction, catalyzed by cheap and nontoxic BiCl 3 , proceeds with short reaction times under mild conditions and normal atmosphere. Only water and alcohol are formed as co‐products in this green reaction.